G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.
Jaime M BrozowskiRoman G TimoshchenkoD Stephen SerafinBrittney AllynJessica KoontzEmily M RabjohnsRishi R RampersadYinshi RenAmanda M EudyTaylor F HarrisDavid AbrahamDaniel MattoxClinton T RubinMatthew J HiltonJanet RubinNancy L AllbrittonMatthew J BillardTeresa K TarrantPublished in: Stem cell research & therapy (2022)
Our work suggests that GRK3 regulates sphingosine-1-phosphate receptor signaling on bone marrow mesenchymal stem cells by recruiting β-arrestin to the occupied GPCR to promote internalization, and lack of such regulation affects mesenchymal stem cell functionality.