Pyrimidine Nucleosides from Streptomyces sp. SSA28.
Cheng-Dong XuHao-Jian ZhangZhong-Jun MaPublished in: Journal of natural products (2019)
Eleven new pyrimidine nucleosides (1-11) and 12 known analogues (12-23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 2-16 were investigated by ECD calculations. Compounds 11-16 showed cytotoxicity against HCT-116 human colon cancer cell lines with IC50 values from 0.39 ± 0.03 to 6.63 ± 0.47 μM.
Keyphrases
- high resolution
- molecular docking
- endothelial cells
- molecular dynamics simulations
- magnetic resonance
- electronic health record
- density functional theory
- molecular dynamics
- big data
- electron microscopy
- induced pluripotent stem cells
- atomic force microscopy
- machine learning
- mass spectrometry
- artificial intelligence
- data analysis
- crystal structure
- deep learning
- cell death