Enhancing the Anticancer and Anti-Inflammatory Properties of Curcumin in Combination with Quercetin, for the Prevention and Treatment of Prostate Cancer.
Michele PellegrinoEmilia BevacquaLuca FrattaruoloAnna Rita CappelloStefano AquaroPaola TucciPublished in: Biomedicines (2023)
Prostate cancer is the second most common cancer in men. Although epidemiologic studies show that a higher intake of polyphenols, curcumin (CUR), and quercetin (QRT), in particular, result in lower prostate cancer risk, the chemopreventive mechanisms underlying the effects of CUR and QRT have not been fully understood yet, and most investigations were conducted with individual compounds. Here, we investigated the anticancer and anti-inflammatory effects of CUR in combination with QRT, respectively, in a human prostate cancer cell line, PC-3, and in LPS-stimulated RAW 264.7 cells, and found that their combination significantly inhibited proliferation and arrested the cell cycle, inducing apoptosis, so exhibiting synergic activities stronger than single drug use. Moreover, via their antioxidant effects, the combination of CUR and QRT modulated several inflammation-mediated signaling pathways (ROS, nitric oxide, and pro-inflammatory cytokines) thus helping protect cells from undergoing molecular changes that trigger carcinogenesis. Although additional studies, including in vivo experiments and translational studies, are required, this study raises the possibility of their use as a safe, effective, and affordable therapeutic approach to prostate cancer.
Keyphrases
- prostate cancer
- anti inflammatory
- radical prostatectomy
- cell cycle
- oxidative stress
- nitric oxide
- cell cycle arrest
- induced apoptosis
- signaling pathway
- case control
- cell death
- endothelial cells
- endoplasmic reticulum stress
- dna damage
- inflammatory response
- squamous cell carcinoma
- epithelial mesenchymal transition
- papillary thyroid
- hydrogen peroxide
- combination therapy
- middle aged
- body mass index
- mass spectrometry
- induced pluripotent stem cells
- reactive oxygen species
- lymph node metastasis
- atomic force microscopy
- weight gain