Purkinje cell dysfunction causes disrupted sleep in ataxic mice.

Luis E Salazar LeonAmanda M BrownHeet KakuRoy V Sillitoe

Published in: bioRxiv : the preprint server for biology (2023)

Utilizing a precise genetic mouse model of ataxia, we provide insights into the cerebellum's role in sleep regulation, highlighting its potential as a therapeutic target for motor disorders-related sleep disruptions.

Keyphrases

sleep quality
mouse model
physical activity
single cell
oxidative stress
genome wide
cell therapy
stem cells
depressive symptoms
type diabetes
metabolic syndrome
dna methylation
high fat diet induced
bone marrow
insulin resistance
skeletal muscle
functional connectivity
wild type