The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition.

Michela PucciInês Gomes FerreiraNadia MalagoliniManuela Ferracin Fabio Dall'Olio

Published in: International journal of molecular sciences (2020)

B4GALNT2/Sda inhibits the stemness-associated malignant phenotype, independently of sLex inhibition. The impact of glycosyltransferases on the phenotype and the transcriptome is highly cell-line specific.

Keyphrases

stem cells
epithelial mesenchymal transition
gene expression
rna seq
single cell
genome wide
dna methylation