Cognitive Dysfunction in Patients Treated with Androgen Deprivation Therapy: A Multimodality Functional Imaging Study to Evaluate Neuroinflammation.
Azeem SaleemSyed Imran Ali ShahStephen A MangarChristopher CoelloMatthew B WallGaia RizzoTerry JonesPatricia M PricePublished in: Prostate cancer (2023)
We found no difference in neuroinflammation measured by PET-TSPO between patients with rCI and rNC. However, we speculate that the strong correlation between TSPO uptake and BOLD-fMRI activation in brain regions involved in memory and known to have high androgen-receptor expression mediating plasticity (hippocampus and amygdala) might reflect inflammatory effects of ADT with compensatory upregulated/increased synaptic functions. Further studies of this imaging readout are warranted to investigate ADT-related CI.
Keyphrases
- resting state
- functional connectivity
- cerebral ischemia
- high resolution
- pet imaging
- cognitive impairment
- traumatic brain injury
- prefrontal cortex
- lipopolysaccharide induced
- lps induced
- computed tomography
- oxidative stress
- white matter
- working memory
- subarachnoid hemorrhage
- multiple sclerosis
- stem cells
- inflammatory response
- fluorescence imaging
- mass spectrometry
- smoking cessation