Prevalence, Morbidity, and Mortality of 1,609 Men with Sex Chromosome Aneuploidy: Results from the Diverse Million Veteran Program Cohort.

Shanlee M DavisCraig TeerlinkJulie A LynchBryan R GormanMeghana PagadalaAoxing LiuMatthew S PanizzonVictoria C MerrittGiulio GenoveseSaiju PyarajanJudith L RossRichard L Hauger

Published in: medRxiv : the preprint server for health sciences (2023)

Comparable to the general population, approximately 1 in 370 male veterans have a sex chromosome aneuploidy, but most are undiagnosed.Men with X or Y chromosome aneuploidy successfully complete US miliary duty with similar service history compared to their 46,XY peers.Medical comorbidities and healthcare utilization metrics are higher in male veterans with 47,XXY and 47,XYY during aging, however life expectancy is similar to matched controls.

Keyphrases

healthcare
copy number
middle aged
mental health
risk factors
quality improvement
gene expression
genome wide
social media