Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA).
Roger A AshmusYang WangManuel González-CuestaDustin T KingBen TietPierre-André GilorminiJosé Manuel García FernándezCarmen Ortiz MelletRobert A BrittonDavid J VocadloPublished in: Organic & biomolecular chemistry (2021)
We report the rational design and synthesis of C2-modified DGJ analogues to improve the selective inhibition of human GALA over other glycosidases. We prepare these analogues using a concise route from non-carbohydrate materials and demonstrate the most selective inhibitor 7c (∼100-fold) can act in Fabry patient cells to drive reductions in levels of the disease-relevant glycolipid Gb3.