Analysis of the humoral and cellular response after the third COVID-19 vaccination in patients with autoimmune hepatitis.
Johannes HartlDarius Ferenc RütherPaul Maria DuengelhoefThomas Theo BrehmSilja SteinmannJan Philipp WeltzschFabian GlaserMartina SterneckMarcial SebodeChristina Weiler-NormannMarc LütgehetmannGolda Melina SchaubFriedrich HaagChristoph SchrammJulian Schulze Zur WieschAnsgar Wilhelm LohsePublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
A third COVID-19 vaccination efficiently boosts antibody levels and T-cell responses in AIH patients and even seroconversion in patients with the absent immune response after two vaccinations, but to a lower level compared to controls. Therefore, we suggest routinely assessing antibody levels in AIH patients and offering additional booster vaccinations to those with suboptimal responses.