Metabolomic prediction of breast cancer treatment induced neurological and metabolic toxicities.
Max PiffouxJérémie JacqueminMélanie PétéraStéphanie DurandAngélique AbilaDelphine CentenoCharlotte JolyBernard LyanAnne-Laure MartinSibille EverhardSandrine BoyaultBarbara PistilliMarion FournierPhilippe RouanetJulie HavasBaptiste SautereyMario CamponeCarole TarpinMarie-Ange Mouret-ReynierOlivier RigalThierry PetitChristine LassetAurélie BertautPaul-Henri CottuFabrice AndreInes Vaz LuisEstelle Pujos-GuillotYouenn DrouetOlivier TrédanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Untargeted high-resolution metabolomics allows better toxicity prediction by considering environmental exposure, metabolites linked to microbiota, and low-frequency metabolites.
Keyphrases
- mass spectrometry
- high resolution
- ms ms
- high glucose
- oxidative stress
- diabetic rats
- liquid chromatography
- drug induced
- human health
- combination therapy
- gas chromatography mass spectrometry
- risk assessment
- endothelial cells
- cerebral ischemia
- young adults
- high resolution mass spectrometry
- brain injury
- stress induced
- simultaneous determination
- childhood cancer