Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice.
Minghui WangShangsheng YaoDehua HeMulan QaharJinqing HeMeifang YinJun WuGuang YangPublished in: Journal of diabetes research (2022)
T2DM inhibited hair follicle regeneration and skin cells proliferation by inhibiting WNT-dependent Lgr5 HFSC activation. This may be an important reason for the reduction of skin renewal ability and the formation of chronic wounds caused by diabetes. It is important for the treatment of chronic diabetic wounds and the development of tissue engineering.
Keyphrases
- wound healing
- stem cells
- tissue engineering
- signaling pathway
- type diabetes
- induced apoptosis
- soft tissue
- cell proliferation
- cardiovascular disease
- glycemic control
- cell cycle arrest
- high fat diet induced
- metabolic syndrome
- skeletal muscle
- mesenchymal stem cells
- endoplasmic reticulum stress
- oxidative stress
- cell therapy
- combination therapy
- weight loss