Dental pain report in children and genetic polymorphism (rs4818) in Catechol-O-Methyltransferase (COMT) gene: a cross- sectional study.
Bruna Leticia Vessoni MenoncinAluhe Lopes FatturiRafaela ScariotJose Vitor Nogara Borges de MenezesJoão Armando BrancherJuliana Feltrin de SouzaPublished in: Journal of applied oral science : revista FOB (2024)
The rs4818 polymorphism of the COMT gene is associated with dental pain. Children with the C allele are more likely to report higher levels of pain. Clinical Relevance: Even though the experience of pain is subjective and multifactorial, this study raises the hypothesis that there is a genetic predisposition to dental pain that should be considered in clinical practice.