A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma.

Wei ZhaiRujian ZhuJunjie MaDongkui GongHaimin ZhangJin ZhangYonghui ChenYiran HuangJunhua ZhengWei Xue

Published in: Molecular cancer (2019)

Our data suggests that targeting this newly identified feed-back loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling may enhance the efficacy of existing therapy and potentially imparts a new avenue to develop more potent therapeutic approaches to suppress RCC progression.

Keyphrases

signaling pathway
transcription factor
pi k akt
cell proliferation
long non coding rna
long noncoding rna
big data
artificial intelligence
drug delivery
anti inflammatory
smoking cessation