Sirtuin 3 Mediated by Spinal cMyc-Enhancer of Zeste Homology 2 Pathway Plays an Important Role in Human Immunodeficiency Virus-Related Neuropathic Pain Model.

Xun ZhuHyun YiJun GuShue LiuKentaro HayashiDaigo IkegamiMarta PardoMichal ToborekSabita RoyHeng LiRoy C LevittShuanglin Hao

Published in: Anesthesia and analgesia (2024)

These results demonstrated that spinal Sirt3 decrease in gp120M-induced neuropathic pain was mediated by cMyc-EZH2/H3K27me3 activity in an epigenetic manner. This study provided new insight into the mechanisms of neuropathic pain in HIV patients with chronic opioids.

Keyphrases

neuropathic pain
human immunodeficiency virus
spinal cord
antiretroviral therapy
hepatitis c virus
spinal cord injury
hiv infected
hiv positive
hiv aids
dna methylation
gene expression
diabetic rats
oxidative stress
chronic pain
pain management
high glucose
hiv testing
binding protein
long noncoding rna