Regional cerebral blood flow in major depression treated with electroconvulsive therapy: an arterial spin labeling magnetic resonance study.
Yuanhong ShiJie LiPing TongJing YangHongying ZhangLiping DongPublished in: Neurocase (2022)
Until recently, regional cerebral blood flow (rCBF) in major depressive disorder (MDD) patients treated with electroconvulsive therapy (ECT) using arterial spin labeling (ASL) magnetic resonance imaging (MRI) have seldom been studied. We report here 10 patients with MDD treated by bilateral frontotemporal ECT. rCBF was assessed with ASL MRI pre- and post-ECT, and compared with patients treated by antidepressants. Compared to pre-ECT, rCBF significantly decreased in the bilateral frontal gyrus. Compared to medication, in patients treated with ECT, rCBF showed a significant decrease in the left amygdala, parahippocampal and olfactory gyrus, and right occipital, lingual, calcarine gyrus, and significantly increased in the bilateral frontal gyrus and right frontal gyrus. Compared with antidepressants, ECT altered rCBF, and showed potential to be a superior treatment for major depressive disorder.
Keyphrases
- major depressive disorder
- cerebral blood flow
- magnetic resonance imaging
- bipolar disorder
- contrast enhanced
- functional connectivity
- magnetic resonance
- working memory
- resting state
- case report
- computed tomography
- room temperature
- diffusion weighted imaging
- density functional theory
- healthcare
- single molecule
- risk assessment
- emergency department
- climate change
- drug induced