Untargeted metabolomic profiling of Prinsepia utilis Royle leaves by Ultra-Performance Liquid Chromatography-Quadrupole-Time of Flight-Mass Spectrometry.
Kiran ChauhanPiyush BhallaKhushaboo BhadoriyaVinay Kumar VarshneyPublished in: Journal of mass spectrometry : JMS (2024)
Prinsepia utilis Royle, native to the Himalayas, is esteemed in Chinese and Indian folk medicine for its diverse medicinal benefits, targeting arthritis, pain relief, bone disorders, and joint discomfort. This study examined the 25% aqueous methanol extract of P. utilis leaves using UPLC-Q-TOF-MS/MS, identifying 78 metabolites, 76 of which were reported for the first time in P. utilis. These included 64 phenolics represented by 56 flavonoids, 5 phenolic acids, 3 phenolic glycosides, 4 terpenoids, 2 lignan glycosides, and 8 other compounds, expanding the knowledge of its chemical composition. These findings lay a foundation for further research, providing insights into potential bioactive compounds and opening avenues for applications in natural product drug discovery, traditional medicine, and nutraceutical development, leveraging the plant's established traditional uses.
Keyphrases
- mass spectrometry
- liquid chromatography
- drug discovery
- high resolution mass spectrometry
- tandem mass spectrometry
- simultaneous determination
- high resolution
- ms ms
- gas chromatography
- high performance liquid chromatography
- chronic pain
- rheumatoid arthritis
- healthcare
- multiple sclerosis
- oxidative stress
- ionic liquid
- risk assessment
- essential oil
- solid phase extraction
- neuropathic pain
- pain management
- soft tissue
- single cell
- bone loss
- cancer therapy
- spinal cord
- spinal cord injury
- anti inflammatory
- carbon dioxide
- gas chromatography mass spectrometry