Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome.

David A DorwardChristopher D LucasMary K DohertyGavin B ChapmanEmma J ScholefieldAndrew Conway MorrisJennifer M FeltonTiina KipariDuncan C HumphriesCalum T RobbA John SimpsonPhillip D WhitfieldChristopher HaslettKevin DhaliwalAdriano G Rossi

Published in: Thorax (2017)

We provide the first definitive evidence of mitochondrial formylated peptides in human disease and demonstrate them to be elevated in ARDS and important in a mouse model of lung injury. This work reveals mitochondrial formylated peptide FPR1 signalling as a key driver of sterile acute lung injury and a potential therapeutic target in ARDS.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
oxidative stress
mouse model
endothelial cells
intensive care unit
lps induced
risk assessment
inflammatory response
climate change
radiation therapy
rectal cancer