Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension.
Moritz I WimmerHendrik BartolomaeusHarithaa AnandakumarChia-Yu ChenValentin VeceraSarah M KedzioraSakshi KambojFabian SchumacherSidney PalsAriana RauchJutta MeiselOlena PotapenkoAlex YarrituTheda Ulrike Patricia BartolomaeusMariam SamaanArne ThieleLucas StürzbecherSabrina Y GeisbergerBurkhard KleuserPeter J OefnerNadine HaaseUlrike LoeberWolfram GronwaldSofia Kirke Forslund-StartcevaDominik N MullerNicola WilckPublished in: Acta physiologica (Oxford, England) (2024)
Metformin modulated the gut microbiome, increased SCFA production, and ameliorated blood pressure and cardiac remodeling in dTGR. Our findings confirm the protective effects of metformin in the absence of diabetes, highlighting SCFA as a potential mediators.