Contribution of BRCA1 and BRCA2 germline mutations to early onset breast cancer: a series from north of Morocco.

Joaira BakkachMohamed MansouriTouria DerkaouiAli LoudiyiElMostafa El FahimeAmina BarakatNaima Ghailani NouroutiJaime Martinez De VillarrealCarlos Cortijo BringasMohcine Bennani Mechita

Published in: BMC cancer (2020)

Our data do not support the hypothesis that BRCA mutations alone explain the higher frequency of breast cancer in Moroccan young women. The young age (≤40 years) for breast cancer diagnosis seems to be strongly predictive of BRCA mutation status in Moroccan patients. These results will help in decision making with regard to genetic counseling and testing in the national scale.

Keyphrases

breast cancer risk
early onset
decision making
late onset
end stage renal disease
ejection fraction
newly diagnosed
dna repair
prognostic factors
genome wide
quality improvement
patient reported outcomes
machine learning
dna damage
deep learning
data analysis
antiretroviral therapy