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Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments.

Xiaohua GuoRebecca A EitnierRichard S BeardJamie E MeeganXiaoyuan YangAlexandra M AponteFang WangPeter R NelsonMack H Wu
Published in: PloS one (2020)
The FAK-Src pathway contributes to γC-induced microvascular barrier dysfunction, junction protein phosphorylation and disorganization in a manner that involves RhoA and stress-fiber formation.
Keyphrases
  • tyrosine kinase
  • protein kinase
  • high glucose
  • diabetic rats
  • cell migration
  • oxidative stress
  • drug induced
  • stress induced
  • endothelial cells
  • escherichia coli
  • staphylococcus aureus
  • cystic fibrosis