Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes.
Noemi BruscoGuido SebastianiGianfranco Di GiuseppeGiada LicataGiuseppina Emanuela GriecoDaniela FignaniLaura NigiCaterina FormichiElena AielloStefano AuddinoGiuseppe QueroChiara Maria Assunta CefaloFrancesca CintiAndrea MariPietro Manuel FerraroAlfredo PontecorviSergio AlfieriAndrea GiaccariFrancesco DottaTeresa MezzaPublished in: Diabetologia (2022)
Our study suggests that increased beta cell workload is accompanied by a progressive increase in ER stress with defects in insulin synthesis and loss of beta cell identity.