Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis.
Malin C ErlandssonLovisa LyngfeltN David ÅbergCaroline WasénRachelle A EspinoSofia Töyrä SilfverswärdMitra NadaliKatharina JoodKarin M E AnderssonRille PulleritsMaria I BokarewaPublished in: BMC medicine (2019)
Low serum IGF1 precedes and predicts development of early CVD events in female RA patients. Hypertension and aberrant IGF1 receptor signaling are highlighted as the important contributors to IGF1-related CVD events.
Keyphrases
- cardiovascular events
- rheumatoid arthritis
- blood pressure
- pi k akt
- binding protein
- end stage renal disease
- growth hormone
- coronary artery disease
- newly diagnosed
- disease activity
- ejection fraction
- cardiovascular disease
- chronic kidney disease
- peritoneal dialysis
- ankylosing spondylitis
- type diabetes
- systemic lupus erythematosus
- signaling pathway
- cell proliferation
- patient reported outcomes
- systemic sclerosis
- idiopathic pulmonary fibrosis