Erythrocytic α-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease.

Ying YangTessandra StewartCan ZhangPan WangZhi XuJinghua JinYang HuangZongran LiuGuoyu LanXingguang LiangLifu ShengMin ShiZhijian CaiJing Zhang

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

By demonstrating the transportation of α-synuclein through RBC-EVs to the GIT, and its potential association with gut-vascular barrier markers and gut microbiome, this work highlights a potential mechanism by which RBC α-synuclein may impact PD initiation and/or progression. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

red blood cell
white matter
multiple sclerosis
cerebral ischemia
brain injury
climate change
subarachnoid hemorrhage