The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila.

Alejandro SaettoneJyoti GargJean-Philippe LambertSyed Nabeel-ShahMarcelo PonceAlyson BurtchCristina Thuppu MudaligeAnne-Claude GingrasRonald E PearlmanJeffrey Fillingham

Published in: Epigenetics & chromatin (2018)

Our results suggest that through recognizing specific histones marks, Ibd1 targets active chromatin regions of highly expressed genes in Tetrahymena where it subsequently might coordinate the recruitment of several chromatin-remodeling complexes to regulate the transcriptional landscape of vegetatively growing Tetrahymena cells.

Keyphrases

genome wide
transcription factor
gene expression
dna damage
dna methylation
genome wide identification
induced apoptosis
ulcerative colitis
oxidative stress
binding protein
heat shock
signaling pathway
endoplasmic reticulum stress
amino acid
small molecule