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Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis.

Jens ThielFranziska M SchmidtRaquel LorenzettiArianna TroiloIga JanowskaLena NießenSophie PfeifferJulian StaniekBruno BenassiniMarei-Theresa BottJakov KorzhenevichLukas KonstantinidisFrank BurgbacherAnn-Katrin DufnerNatalie FredeReinhard E VollJan StuchlyMarina BakardjievaTomas KalinaCristian Roberto SmulskiNils VenhoffMarta Rizzi
Published in: Annals of the rheumatic diseases (2024)
Prolonged depletion of B cells in patients with AAV after RTX therapy indicates a B-cell defect that is unmasked by RTX treatment. Our data indicate that impaired bone marrow B-lymphopoiesis results in a delayed recovery of peripheral B cells that may be further aggravated by a survival defect of B cells. Our findings contribute to the understanding of AAV pathogenesis and may have clinical implications regarding RTX retreatment schedules and immunomonitoring after RTX therapy.
Keyphrases
  • bone marrow
  • mesenchymal stem cells
  • gene therapy
  • stem cells
  • machine learning
  • replacement therapy