COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors.
Lucas G A FerreiraMarina M L KizysGabriel A C GamaSvenja PacherneggGorjana RobevskaAndrew H SinclairKatie L AyersMagnus Régios Dias-da-SilvaPublished in: Cell & bioscience (2024)
Our findings suggest that COUP-TFII has a role in maintaining a multipotent state necessary for commitment to the ovarian development. We propose that COUP-TFII regulates cell fate during gonad development and impairment of its function may disrupt the transcriptional plasticity of ESGCs. During early gonad development, disruption of ESGC plasticity may drive them into commitment to the testicular pathway, as observed in 46,XX OT-DSD patients with NR2F2 haploinsufficiency.