Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4.
Francesco De LoguGabriela TrevisanIlaria Maddalena MaroneElisabetta CoppiDiéssica Padilha DalenogareMustafa TitizMatilde MariniLorenzo LandiniDaniel Souza Monteiro de AraujoSimone Li PumaSerena MaterazziGaetano De SienaPierangelo GeppettiRomina NassiniPublished in: BMC biology (2020)
Targeting of peripheral TRPA1 and central TRPV4 may be required to attenuate pain associated with CIPN elicited by thalidomide and related drugs.