Levcromakalim, an Adenosine Triphosphate-Sensitive Potassium Channel Opener, Dilates Extracerebral but not Cerebral Arteries.
Mohammad Al-Mahdi Al-KaragholiHashmat GhanizadaJakob M HansenLene T SkovgaardJes OlesenHenrik B W LarssonFaisal M AminMessoud AshinaPublished in: Headache (2019)
Levcromakalim dilated the MMA but not MCA. The MMA dilation was associated with headache. Future studies should investigate whether opening of KATP channels can activate and sensitize the perivascular nociceptors.