Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies.
Marie-Lucile FigueresSarah BruneauCaroline Prot-BertoyeGaëlle BrideauMélanie NéelCamille GriveauLydie ChevalYohan BignonJordan DimitrovThomas DejoieSimon VilleChristine Kandel-AznarAnne MoreauPascal HouillierFadi FakhouriPublished in: Journal of the American Society of Nephrology : JASN (2022)
Pathogenic claudin-16 autoantibodies represent a novel autoimmune cause of specific renal tubular transport disturbances and tubulointerstitial nephropathy. Screening for autoantibodies targeting claudin-16, and potentially other magnesium transporters or channels in the kidney, may be warranted in patients with acquired unexplained hypomagnesemia.