HumanMethylation450K Array-Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer.

Mark O KitchenRichard T BryanRichard D EmesChristopher J LuscombeK K ChengMaurice P ZeegersNicholas D JamesLyndon M GommersallAnthony A Fryer

Published in: Biomarkers in cancer (2018)

This is the first genome-wide DNA methylation analysis of a unique HR-NMIBC tumour cohort encompassing known 1-year clinical outcomes. Our analyses identified potential novel epigenetic markers that could help guide individual patient management in this clinically unpredictable disease.

Keyphrases

muscle invasive bladder cancer
dna methylation
genome wide
gene expression
case report
copy number
stress induced
high resolution
high throughput
free survival
climate change
mass spectrometry