SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis.
Julia TilburgDaniëlle M CoenenGaia ZirkaSophie DóllemanAnnemarie M van Oeveren-RietdijkMieke F A KarelHetty C de BoerJudith M E M CosemansHenri H VersteegPierre-Emmanuel MorangeBart J M van VlijmenChrissta X MaracleGrace M ThomasPublished in: Journal of thrombosis and haemostasis : JTH (2020)
These studies corroborate the original GWAS findings and establish a contributing role for SLC44A2 during the initiation of VT, with indications that this may be related to platelet-neutrophil interaction. The precise mechanism however remains elusive and warrants further investigation.
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