Intra-articular Injection of PDGF-BB Explored in a Novel in Vitro Model Mobilizes Mesenchymal Stem Cells From the Synovium Into Synovial Fluid in Rats.

Kentaro EndoKiyotaka HoriuchiHisako KatanoNobutake OzekiYuriko SakamakiHideyuki KogaIchiro Sekiya

Published in: Stem cell reviews and reports (2021)

This novel in vitro model recapitulated the migration of MSCs from synovium into synovial fluid. Our exploration of cytokines revealed that PDGF-BB strongly induced in vitro synovial MSC migration, while intra-articular injection of PDGF-BB increased in vivo MSC numbers in synovial fluid in rats.

Keyphrases

growth factor
smooth muscle
vascular smooth muscle cells
recombinant human
ultrasound guided
mesenchymal stem cells
bone marrow
high glucose
single cell
diabetic rats
drug induced