Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases.
Johan L K Van HoveMarisa W FriederichDana K StrodeRoxanne A Van HoveKristen R MillerRohit SharmaHardik ShahJane EstrellaLinda GabelSimon Peter HorslenRohit KohliMark A LovellAlexander Gerhard MiethkeJean P MollestonRene RomeroJames E SquiresEstella M AlonsoStephen L GutheryBinita M. KamathKathleen M LoomesPhilip RosenthalKrupa R MysoreLaurel A CavalloPamela L ValentinoJohn C MageeShikha S SundaramRonald J Sokolnull nullPublished in: Hepatology communications (2024)
GDF15 and FGF21 are significantly higher in children with MH compared to other childhood liver diseases and controls and, when combined, were predictive of MH and had prognostic implications.