Challenges in Antifungal Therapy in Diabetes Mellitus.
Sazlyna Mohd Sazlly LimMahipal SinnollareddyFekade Bruck SimePublished in: Journal of clinical medicine (2020)
Diabetic patients have an increased propensity to Candida sp. infections due to disease-related immunosuppression and various other physiological alterations. The incidence of candidiasis has increased in number over the years and is linked to significant morbidity and mortality in critically ill and immunosuppressed patients. Treatment of infection in diabetic patients may be complicated due to the various disease-related changes to the pharmacokinetics and pharmacodynamics (PK/PD) of a drug, including antifungal agents. Application of PK/PD principles may be a sensible option to optimise antifungal dosing regimens in this group of patients. Further studies on PK/PD of antifungals in patients with diabetes mellitus are needed as current data is limited or unavailable.
Keyphrases
- candida albicans
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- prognostic factors
- type diabetes
- emergency department
- staphylococcus aureus
- escherichia coli
- bone marrow
- skeletal muscle
- electronic health record
- biofilm formation
- adipose tissue
- mesenchymal stem cells
- drug induced
- patient reported
- replacement therapy