Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes.
Baojun WuSook Wah YeeShujie XiaoFei XuSneha B SridharMao YangSamantha HochstadtWhitney CabralDavid E LanfearMonique M HeddersonKathleen M GiacominiL Keoki WilliamsPublished in: Diabetes care (2023)
We identified a novel and biologically plausible genetic variant associated with a change in HbA1c levels among African American patients on metformin monotherapy. These results highlight the importance of diversity in pharmacogenomic studies.
Keyphrases
- african american
- genome wide association study
- end stage renal disease
- genome wide
- ejection fraction
- chronic kidney disease
- copy number
- type diabetes
- peritoneal dialysis
- prognostic factors
- gene expression
- open label
- metabolic syndrome
- patient reported outcomes
- skeletal muscle
- study protocol
- insulin resistance
- case control