L-Tryptophan-based pyrene conjugate for intracellular zinc-guided excimer emission and controlled nano-assembly.
Surabhi AsthanaTarkeshwar MaddeshiyaArpna TamrakarPraveen KumarNeha GargMrituanjay D PandeyPublished in: Analytical methods : advancing methods and applications (2024)
This article describes intracellular zinc-induced excimer emission and tuning of self-assembly from L-tryptophan-pyrene conjugate (1). The zinc-guided excimer formation is due to the interaction of the pyrene moiety in an excited state. AFM studies show the structural modification in the supramolecular nano-assembly of 1 from dome-shaped to porous surface after complexation with zinc ions. Further, the interaction of 1 with Zn(II) ion is also studied using DFT, Job's plot, NMR titration and HRMS. The results of Zn(II) ion determination in natural water samples and RAW 264.7 cells demonstrate the practical utility of 1.
Keyphrases
- oxide nanoparticles
- solid state
- induced apoptosis
- magnetic resonance
- cancer therapy
- high resolution
- diabetic rats
- high glucose
- cell cycle arrest
- oxidative stress
- water soluble
- signaling pathway
- drug delivery
- density functional theory
- molecular docking
- risk assessment
- endoplasmic reticulum stress
- endothelial cells
- pi k akt
- molecular dynamics simulations
- molecularly imprinted
- crystal structure