A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization.

Nicolas De LeirisPascale PerretCharlotte LombardiBülent GözelSabine ChiericiPhilippe MilletMarlène DebiossatSandrine BacotBenjamin B TournierPatrick ChamesJean-Luc LenormandCatherine GhezziDaniel FagretMarcelle Moulin

Published in: Journal of translational medicine (2024)

2C5 demonstrates excellent affinity and specificity for pathological Tau oligomers, particularly in their early stages of oligomerization. However, the current limitation of insufficient blood-brain barrier penetration necessitates further modifications before considering its application in nuclear medicine imaging for humans.

Keyphrases

blood brain barrier
cerebrospinal fluid
high resolution
cerebral ischemia
label free
binding protein
loop mediated isothermal amplification
amino acid
mass spectrometry
quantum dots
capillary electrophoresis