Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats.

Doo Jin ChoiSoo-Im ChoiBo-Ram ChoiYoung-Seob LeeDae Young LeeGeum Soog Kim

Published in: BMC complementary and alternative medicine (2019)

Our results demonstrate that ALM16 has a strong chondroprotective effect against the OA model in vitro and in vivo, likely attributed to its anti-inflammatory activity and inhibition of MMP production.

Keyphrases

knee osteoarthritis
high glucose
diabetic rats
rheumatoid arthritis
neuropathic pain
drug induced
anti inflammatory
extracellular matrix
cell migration
endothelial cells
oxidative stress