Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history.
Carla F Murillo PerezJorn C GoetWillem J LammersAliya GulamhuseinHenk R van BuurenCyriel Y PonsioenMarco CarboneAndrew MasonChristophe CorpechotPietro InvernizziMarlyn J MayoPier Maria BattezzatiAnnarosa FloreaniAlbert ParesFrederik NevensKris V KowdleyKaren SchmidtGeorge N DalekosDouglas ThorburnGideon HirschfieldNicholas F LaRussoKeith D LindorKalliopi ZachouRaoul PouponPalak J TrivediXavier VerhelstHarry L A JanssenBettina E Hansennull nullPublished in: Hepatology (Baltimore, Md.) (2018)
In recent decades, a pattern of primary biliary cholangitis presentation consistent with an older age at diagnosis alongside reduced disease severity has been noted; the observed trends may be explained by an increase in routine testing of liver function and/or a changing environmental trigger. (Hepatology 2018;67:1920-1930).