Advances in Musculoskeletal Imaging in Juvenile Idiopathic Arthritis.
Iwona Sudoł-SzopińskaNele HerregodsAndrea S DoriaMihra S TaljanovicPiotr GietkaNikolay TzaribachevAndrea Sabine KlauserPublished in: Biomedicines (2022)
Over the past decade, imaging of inflammatory arthritis in juvenile arthropathies has significantly advanced due to technological improvements in the imaging modalities and elaboration of imaging recommendations and protocols through systematic international collaboration. This review presents the latest developments in ultrasound (US) and magnetic resonance imaging (MRI) of the peripheral and axial joints in juvenile idiopathic arthritis. In the field of US, the ultra-wideband and ultra-high-frequency transducers provide outstanding spatial resolution. The more sensitive Doppler options further improve the assessment and quantification of the vascularization of inflamed tissues, and shear wave elastography enables the diagnosis of tissue stiffness. Concerning MRI, substantial progress has been achieved due to technological improvements in combination with the development of semiquantitative scoring systems for the assessment of inflammation and the introduction of new definitions addressing the pediatric population. New solutions, such as superb microflow imaging, shear wave elastography, volume-interpolated breath-hold examination, and MRI-based synthetic computed tomography open new diagnostic possibilities and, at the same time, pose new challenges in terms of clinical applications and the interpretation of findings.
Keyphrases
- magnetic resonance imaging
- high resolution
- juvenile idiopathic arthritis
- computed tomography
- high frequency
- contrast enhanced
- oxidative stress
- rheumatoid arthritis
- gene expression
- disease activity
- transcranial magnetic stimulation
- diffusion weighted imaging
- mass spectrometry
- fluorescence imaging
- positron emission tomography
- systemic lupus erythematosus
- photodynamic therapy
- single molecule