A comparison study of metabolic profiles, immunity, and brain gray matter volumes between patients with bipolar disorder and depressive disorder.

Ya-Mei BaiMu-Hong ChenJu-Wei HsuKai-Lin HuangPei-Chi TuWan-Chen ChangTung-Ping SuCheng Ta LiWei-Chen LinShih-Jen Tsai

Published in: Journal of neuroinflammation (2020)

Our results suggested that BD patients had higher BMI and pro-inflammatory cytokine levels in comparison to UD patients, especially IL-6 and sTNF-R1, which may contribute to greater gray matter reductions in BD patients in comparison to UD patients. The results support the neuro-inflammation pathophysiology mechanism in mood disorder. It is clinically important to monitor BMI, which, in this investigation, positively correlated with levels of inflammatory cytokines.

Keyphrases

end stage renal disease
bipolar disorder
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
oxidative stress
multiple sclerosis
body mass index
depressive symptoms
sleep quality