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The association of vascular disorders with incident dementia in different age groups.

Nienke LegdeurSven J Van der LeeMarcel de WildeJohan van der LeiMajon MullerAndrea Britta MaierPieter Jelle Visser
Published in: Alzheimer's research & therapy (2019)
We conclude that vascular disorders are no longer a risk factor for dementia at high age. Possible explanations include selective survival of individuals who are less susceptible to the negative consequences of vascular disorders and differences in follow-up time between individuals with and without a vascular disorder. Future research should focus on the identification of other risk factors than vascular disorders, for example, genetic or inflammatory processes, that can potentially explain the strong age-related increase in dementia risk.
Keyphrases
  • mild cognitive impairment
  • risk factors
  • cognitive impairment
  • cardiovascular disease
  • type diabetes
  • oxidative stress
  • gene expression
  • copy number