Lung microhaemorrhage drives oxidative/inflammatory damage in α 1 -antitrypsin deficiency.

Cesare SaltiniNaweed MohammadYan XinRodolfo AlvaradoAndrew J GhioCraig G MoneypennyAlberto RivaDongtao FuTammy FlaggGiovanni F A SaltiniIvan ArisiKristianna M FredenburgYang ZhangJorge E LascanoMark L Brantly

Published in: ERJ open research (2023)

BAL and tissue markers of alveolar haemorrhage, together with molecular and cellular evidence of macrophage innate pro-inflammatory activation and oxidative damage, are consistent with free haem stimulation. Overall, this initial study provides evidence for a pathogenetic role of elastase-induced alveolar haemorrhage in AATD emphysema.

Keyphrases

immune response
oxidative stress
high glucose
adipose tissue
chronic obstructive pulmonary disease
endothelial cells
idiopathic pulmonary fibrosis
lung function
stress induced