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Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms.

Wei WangLiting GuJiahao WangXubin HuBin WeiHua-Wei ZhangHong WangJianwei Chen
Published in: Marine drugs (2023)
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes-cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides-according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds.
Keyphrases
  • small molecule
  • staphylococcus aureus
  • protein protein
  • healthcare
  • drinking water
  • high throughput
  • social media
  • molecular dynamics
  • single cell
  • health information
  • loop mediated isothermal amplification