Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.

Lyanne A Delgado-CokaLucia Roa-PeñaSruthi BabuMichael HorowitzEmanuel F PetricoinLynn M MatrisianEdik M BlaisNatalia MarchenkoFelicia D AllardAli AkalinWei JiangBrent K LarsonAndrew E HendifarVincent J PicozziMinsig ChoiKenneth R ShroyerLuisa F Escobar-Hoyos

Published in: American journal of clinical pathology (2024)

The detection of K17 in 10% or greater of PDAC cells identified patients with shortest survival. Among patients with low K17 PDACs, 5-FU-based treatment was more likely than gemcitabine-based therapies to extend survival.

Keyphrases

induced apoptosis
free survival
cell cycle arrest
squamous cell carcinoma
locally advanced
endoplasmic reticulum stress
cell death
label free