USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart.
Sai-Yang XieShi-Qiang LiuTong ZhangWen-Ke ShiYun XingWen-Xi FangMin ZhangMeng-Ya ChenSi-Chi XuMeng-Qi FanLan-Lan LiHeng ZhangNan ZhaoZhao-Xiang ZengSi ChenXiao-Feng ZengWei DengQi-Zhu TangPublished in: Circulation (2023)
Our findings provide a USP28-modulated mitochondria homeostasis mechanism that involves the PPARα-Mfn2 axis in diabetic hearts, suggesting that USP28 activation or adeno-associated virus therapy targeting USP28 represents a potential therapeutic strategy for diabetic cardiomyopathy.