Given its nonnegligible role in metabolic homeostasis, adipose tissue has been the target for treating metabolic disorders such as obesity, diabetes and cardiovascular diseases. Besides its lipolytic function, adipose thermogenesis has gained increased interest due to the irreplaceable contribution to dissipating energy to restore equilibrium, and its therapeutic effects have been testified in various animal models. In this review, we will brief about the canonical cold-stimulated adipose thermogenic mechanisms, elucidate on the exercise- and intermittent fasting-induced adipose thermogenic mechanisms, with a focus on the similarities and disparities among these signaling pathways, in an effort to uncover the overlapped and specific targets that may yield potent therapeutic efficacy synergistically in improving metabolic health.
Keyphrases
- adipose tissue
- insulin resistance
- high intensity
- high fat diet
- cardiovascular disease
- type diabetes
- high fat diet induced
- metabolic syndrome
- skeletal muscle
- public health
- healthcare
- glycemic control
- resistance training
- physical activity
- signaling pathway
- blood glucose
- affordable care act
- body composition
- body mass index
- diabetic rats
- risk assessment
- blood pressure
- health promotion
- health insurance
- pi k akt
- molecular dynamics
- human health
- climate change