T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes.

Chung-Hsing WangWen-Li LuShang-Lun ChiangTsung-Hsun TsaiSu-Ching LiuChia-Hung HsiehPen-Hua SuChih-Yang HuangFuu-Jen TsaiYu-Jung Lin Yu-Nan Huang

Published in: The Journal of clinical endocrinology and metabolism (2022)

Our findings indicate that Th1 cells induced tubular cell injury through dysregulated metabolic reprogramming and autophagy, thereby indicating a new therapeutic approach for kidney tubular injury in T1DM.

Keyphrases

high glucose
type diabetes
cell death
endoplasmic reticulum stress
induced apoptosis
endothelial cells
signaling pathway
cell cycle arrest
glycemic control
single cell
cardiovascular disease
cell therapy
insulin resistance
diabetic rats
metabolic syndrome
bone marrow
cell proliferation