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Association of Pancreatic Adenocarcinoma Location With DNA Damage Response Status and Response to Platinum-Based Therapy.

Ida MicailyEdik M BlaisRandi CarhartSophia S LamSteven J CohenShawna J CannadayDavid HalversonLynn M MatrisianPatricia DeArbeloaDzung ThachEmanuel PetricoinMichael J PishvaianHarish LavuCharles J YeoAtrayee Basu Mallick
Published in: JCO precision oncology (2023)
are known predictors of increased benefit from platinum-based chemotherapy. NGS testing for germline and somatic mutations remains important in pancreatic ductal adenocarcinoma, especially in BT tumors where DDR pathway alterations may be more common than in H tumors.
Keyphrases
  • dna damage response
  • dna repair
  • locally advanced
  • copy number
  • squamous cell carcinoma
  • mesenchymal stem cells
  • dna methylation
  • radiation therapy
  • bone marrow
  • genome wide
  • smoking cessation