Association of Pancreatic Adenocarcinoma Location With DNA Damage Response Status and Response to Platinum-Based Therapy.
Ida MicailyEdik M BlaisRandi CarhartSophia S LamSteven J CohenShawna J CannadayDavid HalversonLynn M MatrisianPatricia DeArbeloaDzung ThachEmanuel PetricoinMichael J PishvaianHarish LavuCharles J YeoAtrayee Basu MallickPublished in: JCO precision oncology (2023)
are known predictors of increased benefit from platinum-based chemotherapy. NGS testing for germline and somatic mutations remains important in pancreatic ductal adenocarcinoma, especially in BT tumors where DDR pathway alterations may be more common than in H tumors.