Dynamics of Endothelial Cell Generation and Turnover in Arteries During Homeostasis and Diseases.

Yi Li Zixin Liu Ximeng Han Feng Liang Qianyu ZhangXiuzhen HuangXin ShiHuanhuan HuoMaoying HanXiuxiu Liu Huan ZhuLingjuan HeLing-Hong Shen Xinyang Hu Jian'an Wang Qing-Dong Wang Nicola Smart Bin Zhou Ben He

Published in: Circulation (2023)

Genetic proliferation tracing quantitatively delineates the dynamics of EC generation and turnover, as well as EC division orientation, in large vessels during homeostasis and disease. An EC subpopulation in the aorta exhibits more robust cell proliferation during homeostasis and type 2 diabetes, identifying it as a potential therapeutic target for vascular repair and regeneration.

Keyphrases

type diabetes
cell proliferation
bone mineral density
stem cells
endothelial cells
signaling pathway
cardiovascular disease
aortic valve
pulmonary artery
cell cycle
genome wide
insulin resistance
glycemic control
gene expression
skeletal muscle
pulmonary hypertension
blood flow
metabolic syndrome